2020-2016
2015-2011
2010-2006
2005-2001
2000-1996

2020

235.Expeditious Total Synthesis of Hemiasterlin via a Convergent Multi-component Strategy and Its Use in Targeted Cancer Therapeutics, J. Charoenpattarapreeda, S. J. Walsh, J. S. Carroll, D. R. Spring, Angew. Chem. Int. Ed. 2020, 59, in press.
234.Efficient and selective antibody modification with functionalised divinyltriazines, A. J. Counsell, S. J. Walsh, N. S. Robertson, H. F. Sore, D. R. Spring, Org. Biomol. Chem. 2020, 18, 4739-4743.
233.Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells, D. A. Russell, H. R. Bridges, R. Serreli, S. L. Kidd, N. Mateu, T. J. Osberger, H. F. Sore, J. Hirst, D. R. Spring, J. Nat. Prod. 2020, 83, 1829-1845.
232.C(sp3)-H arylation to construct all-syn cyclobutane-based heterobicyclic systems: a novel fragment collection, T. J. Osberger, S. L. Kidd, T. A. King, D. R. Spring, Chem. Commun. 2020, 56, 7423-7426.
231.Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion, S. L. Kidd, E. Fowler, T. Reinhardt, T. Compton, N. Mateu, H. Newman, D. Bellini, R. Talon, J. McLoughlin, T. Krojer, A. Aimon, A. Bradley, M. Fairhead, P. Brear, L. Diaz-Saez, K. McAuley, H. F. Sore, A. Madin, D. H. O'Donovan, K. V. M. Huber, M. Hyvonen, F. von Delft, C. G. Dowson, D. R. Spring, Chem. Sci. 2020, 11, in press.
230.Divergent synthesis of novel cylindrocyclophanes that inhibit methicillin-resistant Staphylococcus aureus (MRSA), J. J. Freudenreich, S. Bartlett, N. S. Robertson, S. L. Kidd, S. Forrest, H. F. Sore, W. R. J. D. Galloway, M. Welch, D. R. Spring, ChemMedChem 2020, 15, 1289-1293.
229.General dual functionalisation of biomacromolecules via a cysteine bridging strategy, S. J. Walsh, J. Iegre, H. Seki, J. D. Bargh, H. F. Sore, J. S. Parker, J. S. Carroll, D. R. Spring, Org. Biomol. Chem. 2020, 18, 4224-4230.
228.Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction, A. V. Strizhak, O. Babii, S. Afonin, I. Bakanovich, T. Pantelejevs, W. Xu, E. Fowler, R. Eapen, K. Sharma, M. O. Platonov, V. V. Hurmach, L. S. Itzhaki, M. Hyvonen, A. S. Ulrich, D. R. Spring I. V. Komarov, Org. Biomol. Chem. 2020, 18, 5359-5369.
227.An efficient, stereocontrolled and versatile synthetic route to bicyclic heteroaromatic privileged scaffolds, H. L. Stewart, A. R. Hanby, T. A. King, A. D. Bond, T. A. Moss, H. F. Sore, D. R. Spring, Chem. Commun. 2020, 56, 6818-6821.
226.Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design, P. R. Curran, C. J. Radoux, M. D. Smilova, R. A. Sykes, A. P. Higueruelo, A. R. Bradley, B. D. Marsden, D. R. Spring, T. L. Blundell, A. R. Leach, W. R. Pitt, J. C. Cole, J. Chem. Inf. Model. 2020, 60, 1911-1916.
225.Sulfatase-cleavable linkers for antibody-drug conjugates, J. D. Bargh, S. J. Walsh, A. Isidro-Llobet, S. Omarjee, J. S. Carroll, D. R. Spring, Chem. Sci. 2020, 11, 2375-2380.
224.2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in Pseudomonas aeruginosa, A. C. McVey, S. Bartlett, M. Kajbaf, A. Pellacani, V. Gatta, P. Tammela, D. R. Spring, M. Welch, Int. J. Mol. Sci. 2020, 21, 2490.
223.Fsp3-Rich and Diverse Fragments Inspired by Natural Products as a Collection to Enhance Fragment-Based Drug Discovery, A. R. Hanby, N. S. Troelsen, T. J. Osberger, S. L. Kidd, K. T. Mortensen, D. R. Spring, Chem. Commun. 2020, 56, 2280-2283.
222.Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents, T. R. Pettigrew, R. J. Porter, S. J. Walsh, M. P. Housden, N. Y. S. Lam, J. S. Carroll, J. S. Parker, D. R. Spring, I. Paterson, Chem. Commun. 2020, 56, 1529-1532.
221.Functionalized double strain-promoted stapled peptides for inhibiting p53-MDM2 interaction, K. Sharma, A. V. Strizhak, E. Fowler, W. Xu, B. Chappell, H. F. Sore, W. R. J. D. Galloway, M. N. Grayson, Y. H. Lau, L. S. Itzhaki, D. R. Spring, ACS Omega 2020, 5, 1157-1169.
220.Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1, D. J. Huggins, B. S. Hardwick, P. Sharma, A. Emery, L. Laraia, F. Zhang, A. J. Narvaez, M. Roberts-Thomson, A. T. Crooks, R. G. Boyle, R. Boyce, D. W. Walker, N. Mateu, G. J. McKenzie, D. R. Spring, A. R. Venkitaraman, ACS Omega 2020, 5, 822-831.

2019

219.Direct synthesis of N-functionalized dipropargylamine linkers as models for use in peptide stapling, A. Renzetti, R. N. Rutherford, K. Fukumoto, D. Kunciw, H. F. Sore, D. R. Spring, Synlett 2019, 30, 2153-2156.
218.A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation, P. Sharma, R. Mahen, M. Rossman, J. E. Stokes, B. Hardwick, D. J. Huggins, A. Emery, D. L. Kunciw, M. Hyvonen, D. R. Spring, G. J. McKenzie, A. R. Venkitaraman, Sci. Rep. 2019, 9, 15930.
217.Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry, K. Sharma, A. V. Strizhak, E. Fowler, X. Wang, W. Xu, C. Hatt Jensen, Y. Wu, H. F. Sore, Y. H. Lau, M. Hyvonen, L. S. Itzhaki, D. R. Spring, Org. Biomol. Chem. 2019, 17, 8014-8018.
216.Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment-Based Drug Discovery, T. A. King, H. L. Stewart, K. Mortensen, A. J. P. North, H. F. Sore, D. R. Spring, Eur. J. Org. Chem. 2019, 2019, 5219-5229.
215.Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling, N. S. Robertson, S. J. Walsh, E. Fowler, M. Yoshida, S. M. Rowe, Y. Wu, H. F. Sore, J. S. Parker, D. R. Spring, Chem. Commun. 2019, 55, 9499-9502.
214.Cleavable linkers in antibody-drug conjugates, J. D. Bargh, A. Isidro-Llobet, J. S. Parker, D. R. Spring, Chem. Soc. Rev. 2019, 48, 4361-4374.
213.Strategies for the Diversity-Oriented Synthesis of Macrocycles, K. T. Mortensen, T. J. Osberger, T. A. King, H. F. Sore, D. R. Spring, Chem. Rev. 2019, 119, 10288-10317.
212.Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection, A. Sveiczer, A. J. P. North, N. Mateu, S. L. Kidd, H. F. Sore, D. R. Spring, Org. Lett. 2019, 21, 4600-4604.
211.Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides, J. Charoenpattarapreeda, Y. S. Tan, J. Iegre, S. J. Walsh, E. Fowler, R. S. Eapen, Y. Wu, H. F. Sore, C. S. Verma, L. Itzhaki, D. R. Spring, Chem. Commun. 2019, 55, 7914-7917.
210.Efficient development of stable and highly functionalised peptides targeting the CK2a/CK2b protein-protein interaction, J. Iegre, P. Brear, D. J. Baker, Y. S. Tan, E. L. Atkinson, H. Sore, D. H. O'Donovan, C. Verma, M. Hyvonen, D. R. Spring, Chem. Sci. 2019, 10, 5056-5063.
209.Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides, Y. Wu, A. Kaur, E. Fowler, M. M. Wiedmann, R. Young, W. R. J. D. Galloway, L. Olsen, H. F. Sore, A. Chattopadhyay, T. T.-L. Kwan, W. Xu, S. J. Walsh, P. de Andrade, M. Janecek, S. Arumugam, L. S. Itzhaki, Y. H. Lau, D. R. Spring, ACS Chem. Bio. 2019, 14, 526-533.
208.Synthesis and Reactivity of a Bis-Strained Alkyne Derived from 1,1'-Biphenyl-2,2',6,6'-tetrol, R. C. Knighton, K. Sharma, N. S. Robertson, D. R. Spring, M. Wills, ACS Omega 2019, 4, 2160-2167.
207.A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates, S. J. Walsh, S. Omarjee, W. R. J. D. Galloway, T. T.-L. Kwan, H. F. Sore, J. S. Parker, M. Hyvonen, J. S. Carroll, D. R. Spring, Chem. Sci. 2019, 10, 694-700.

2018

206.Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking, A. V. Strizhak, K. Sharma, O. Babii, S. Afonin, A. S. Ulrich, I. V. Komarov, D. R. Spring, Org. Biomol. Chem. 2018, 16, 8559-8564.
205.Synthesis and biological evaluation of 1,2-disubstituted 4-quinolone analogues of Pseudonocardia sp. natural products, S. M. Geddis, T. Coroama, S. Forrest, J. T. Hodgkinson, M. Welch, D. R. Spring, Beilstein J. Org. Chem. 2018, 14, 2680-2688.
204.Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections, S. L. Kidd, T. J. Osberger, N. Mateu, H. F. Sore, D. R. Spring, Front. Chem. 2018, 6, 460.
203.Semi-syntheses of the 11-hydroxyrotenoids sumatrol and villosinol, D. A. Russell, J. J. Freudenreich, H. L. Stewart, A. D. Bond, H. F. Sore, D. R. Spring, Org. Biomol. Chem. 2018, 16, 6395-6398.
202.Synthesis of Structurally Diverse N-Substituted Quaternary-Carbon-Containing Small Molecules from a,a-Disubstituted Propargyl Amino Esters, N. Mateu, S. L. Kidd, L. Kalash, H. F. Sore, A. Madin, A. Bender, D. R. Spring, Chem. Eur. J. 2018, 24, 13681-13687.
201.The Application of Diversity-Oriented Synthesis in Chemical Biology, N. Mateu, S. L. Kidd, T. J. Osberger, H. L. Stewart, S. Bartlett, W. R. J. D. Galloway, A. J. P. North, H. F. Sore, D. R. Spring, In "Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology" Ed. J N. J. Westwood, A. Nelson 2018, The Royal Society of Chemistry, 8-44.
200.Two-Component Stapling of Biologically Active and Conformationally Constrained Peptides: Past, Present, and Future, J. Iegre, J. S. Gaynord, N. S. Robertson, H. F. Sore, M. Hyvonen, D. R. Spring, Adv. Therap. 2018, 1, 1800052.
199.Synthesis of structurally diverse biflavonoids, T. J. Sum, T. H. Sum, W. R. J. D. Galloway, D. G. Twigg, J. J. Ciardiello, D. R. Spring, Tetrahedron 2018, 74, 5089-5101.
198.Novel non-ATP competitive small molecules targeting the CK2 a/b interface, P. Brear, A. North, J. Iegre, K. Hadje Georgiou, A. Lubin, L. Carro, W. Green, H. F. Sore, M. Hyvonen, D. R. Spring, Bioorg. Med. Chem. 2018, 26, 3016-3020.
197.Stapled peptides as a new technology to investigate protein-protein interactions in human platelets, J. Iegre, N. S. Ahmed, J. S. Gaynord, Y. Wu, K. M. Herlihy, Y. S. Tan, M. E. Lopes-Pires, R. Jha, Y. H. Lau, H. Sore, C. Verma, D. H. O'Donovan, N. Pugh, D. R. Spring, Chem. Sci. 2018, 9, 4638-4643.
196.Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein-Protein Interactions, N. S. Robertson, D. R. Spring, Molecules 2018, 23, 959.
195.Large-scale production of biologically active violacein and deoxyviolacein from synthetic operons, E. Bilsland, T. A. Tavella, R. Krogh, J. E. Stokes, A. Roberts, J. Ajioka, D. R. Spring, A. Andricopulo, F. T. M. Costa, S. G. Oliver, BMC Biotechnol. 2018, 18, 22.
194.Bioinspired Total Synthesis of Bussealin E, D. G. Twigg, L. Baldassarre, E. C. Frye, W. R. J. D. Galloway, D. R. Spring, Org. Lett. 2018, 20, 1597-1599.
193.Second-generation CK2a inhibitors targeting the aD pocket, J. Iegre, P. Brear, C. De Fusco, M. Yoshida, S. L. Mitchell, M. Rossmann, L. Carro, H. F. Sore, M. Hyvonen, D. R. Spring, Chem. Sci. 2018, 9, 3041-3049.
192.Loving the poison: the methylcitrate cycle and bacterial pathogenesis, S. K. Dolan, A. Wijaya, S. M. Geddis, D. R. Spring, R. Silva-Rocha, M. Welch, Microbiol. 2018, 164, 251-259.
191.Double-click Stapled Peptides for Inhibiting Protein-Protein Interactions, K. Sharma, D. L. Kunciw, M. M. Wiedmann, Y. Wu, W. Xu, H. F. Sore, W. R. J. D. Galloway, L. S. Itzhaki, D. R. Spring, In "Cyclic Peptides: From Bioorganic Synthesis to Applications" Ed. J. Koehnke, J. Naismith, W. A. van der Donk 2018, The Royal Society of Chemistry, 164-187.

2017

190.Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa, A. McVey, P. Medarametla, X. Chee, S. Bartlett., A. Poso, D. R. Spring, T. Rahman, M. Welch, Biochemistry 2017, 56, 5539-5549.
189.Stereocontrolled Semisyntheses of Elliptone and 12ab-Hydroxyelliptone, D. A. Russell, W. J. S. Fong, D. G. Twigg, H. F. Sore, D. R. Spring, J. Nat. Prod. 2017, 80, 2751-2755.
188.Targeting the genome stability hub Ctf4 by stapled-peptide design, Y. Wu, F. Villa, J. Maman, Y. H. Lau, L. Dobnikar, A. Simon, K. Labib, D. R. Spring, L. Pellegrini, Angew. Chem. Int. Ed. 2017, 56, 12866-12872.
187.Identification of new quorum sensing autoinducer binding partners in Pseudomonas aeruginosa using photoaffinity probes, Y. R. Baker, J. T. Hodgkinson, B. I. Florea, E. Alza, W. R. J. D. Galloway, L. Grimm, S. M. Geddis, S. J. Walsh, H. S. Overkleeft, M. Welch, D. R. Spring, Chem. Sci. 2017, 8, 7403-7411.
186.Computationally-Guided Optimization of Small-Molecule Inhibitors of the Aurora A Kinase - TPX2 Protein-Protein Interaction, D. J. Cole, M. Janecek, J. E. Stokes, M. Rossmann, J. C. Faver, G. J. McKenzie, A. R. Venkitaraman, M. Hyvonen, D. R. Spring, D. J. Huggins, W. L. Jorgensen, Chem. Commun. 2017, 53, 9372-9375.
185.A novel complexity-to-diversity strategy for the diversity-oriented synthesis of structurally diverse and complex macrocycles from quinine, J. J. Ciardiello, H. L. Stewart, H. F. Sore, W. R. J. D. Galloway, D. R. Spring, Bioorg. Med. Chem. 2017, 25, 2825-2843.
184.Diversity-Oriented Synthesis of Heterocycles and Macrocycles by Controlled Reactions of Oxetanes with alpha-Iminocarbenes, A. Guarnieri-Ibanez, F. Medina, C. Besnard, S. L. Kidd, D. R. Spring, J. Lacour, Chem. Sci. 2017, 8, 5713-5720.
183.Divergent synthesis of biflavonoids yields novel inhibitors of the aggregation of amyloid beta (1-42), T. H. Sum, T. J. Sum, S. Collins, W. R. J. D. Galloway, D. G. Twigg, F. Hollfelder, D. R. Spring, Org. Biomol. Chem. 2017, 15, 4554-4570.
182.A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066, C. De Fusco, P. Brear, J. Iegre, K. Hadje Georgiou, H. F. Sore, M. Hyvonen, D. R. Spring, Bioorg. Med. Chem. 2017, 25, 3471-3482.
181.Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(II) catalyst, T. T.-L. Kwan, O. Boutureira, E. C. Frye, S. J. Walsh, M. K. Gupta, S. Wallace, Y. Wu, F. Zhang H. F. Sore, W. R. J. D. Galloway, J. W. Chin, M. Welch, G. J. L. Bernardes, D. R. Spring, Chem. Sci. 2017, 8, 3871-3878.
180.Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase, W. Xu, Y. H. Lau, G. Fischer, Y. S. Tan, A. Chattopadhyay, M. de la Roche, M. Hyvonen, C. Verma, D. R. Spring, L. S. Itzhaki, J. Am. Chem. Soc. 2017, 139, 2245-2256.
179.(Z)-Selective Takai olefination of salicylaldehydes, S. M. Geddis, C. E. Hagerman, W. R. J. D. Galloway, H. F. Sore, J. M. Goodman, D. R. Spring, Beilstein J. Org. Chem. 2017, 13, 323-328.
178.Stereocontrolled semi-syntheses of deguelin and tephrosin, D. A. Russell, J. J. Freudenreich, J. J. Ciardiello, H. F. Sore, D. R. Spring, Org. Biomol. Chem. 2017, 15, 1593-1596.
177.Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer, M. Wiedmann, Y. S. Tan, Y. Wu, S. Aibara, W. Xu, H. F. Sore, C. S. Verma, L. Itzhaki, M. Stewart, J. D. Brenton, D. R. Spring, Angew. Chem. Int. Ed. 2017, 56, 524-529.
176.Complex peptides made simple, S. Bartlett, D. R. Spring, Nat. Chem. 2017, 9, 9-10.

2016

175.Divergent Synthesis of Quinolone Natural Products from Pseudonocardia sp. CL38489, S. M. Geddis, L. Carro, J. T. Hodgkinson, D. R. Spring, Eur. J. Org. Chem. 2016, 2016, 5799-5802.
174.Multiple-Parameter Optimization in Drug Discovery: Example of the 5-HT1B GPCR, R. C. Glen, W. R. J. D. Galloway, D. R. Spring, G. M. Liwicki, Mol. Inf. 2016, 35, 599-605.
173.Partially Saturated Bicyclic Heteroaromatics as an sp3-enriched Fragment Collection, D. G. Twigg, N. Kondo, S. L. Mitchell, W. R. J. D. Galloway, H. F. Sore, A. Madin, D. R. Spring, Angew. Chem. Int. Ed. 2016, 55, 12479-12483.
172.A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles, F. Nie, D. L. Kunciw, D. Wilcke, J. E. Stokes, W. R. J. D. Galloway, S. Bartlett, H. F. Sore, D. R. Spring, Angew. Chem. Int. Ed. 2016, 55, 11139-11143.
171.Specific inhibition of CK2a from an anchor outside the active site, P. Brear, C. De Fusco, K. Hadje-Georgiou, N. J. Francis-Newton, C. J. Stubbs, H. F. Sore, A. R. Venkitaraman, C. Abell, D. R. Spring, M. Hyvonen, Chem. Sci. 2016, 7, 6839-6845.
170.Combinatorial Synthesis of Structurally Diverse Triazole-Bridged Flavonoid Dimers and Trimers, T. H. Sum, T. J. Sum, W. R. J. D. Galloway, S. Collins, D. G. Twigg, F. Hollfelder, D. R. Spring, Molecules 2016, 21, 1230.
169.Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1B (HNF1B) transcription factor is imported into the nucleus via a monopartite NLS sequence, M. M. Wiedmann, S. Aibara, D. R. Spring, M. Stewart, J. D. Brenton, J. Struct. Biol. 2016, 195, 273-281.
168.Discovery of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells, B. Morkunas, B. Gal, W. R. J. D. Galloway, J. T. Hodgkinson, B. M. Ibbeson, Y. S. Tan, M. Welch, D. R. Spring, Beilstein J. Org. Chem. 2016, 12, 1428-1433.
167.Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2, M. Janecek, M. Rossmann, P. Sharma, A. Emery, D. J. Huggins, S. R. Stockwell, J. E. Stokes, Y.-S. Tan, E. Guarino-Almeida, B. Hardwick, A. J. Narvaez, M. Hyvonen, D. R. Spring, G. J. McKenzie, A. R. Venkitaraman, Sci. Rep. 2016, 6, 28528.
166.The Pseudomonas Quinolone Signal (PQS), T. Sams, Y. R. Baker, J. T. Hodgkinson, J. Gross, D. R. Spring, M. Welch, Israel J. Chem. 2016, 56, 282-294.
165.The Reductive Cleavage Of Picolinic Amides, D. H. O' Donovan, C. De Fusco, D. R. Spring, Tetrahedron Lett. 2016, 57, 2962-2964.
164.Diversity-Oriented Synthesis of Macrocycle Libraries for Drug Discovery and Chemical Biology, S. Collins, S. Bartlett, F. Nie, H. F. Sore, D. R. Spring, Synthesis 2016, 48, 1457-1473.
163.Divergent Total Syntheses of Flavonoid Natural Products Isolated from Rosa rugosa and Citrus unshiu, T. J. Sum, T. H. Sum, W. R. J. D. Galloway, D. R. Spring, Synlett 2016, 27, 1725.
162.Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling, Y. Wu, L. B. Olsen, Y. H. Lau, C. H. Jensen, M. Rossmann, Y. R. Baker, H. F. Sore, S. Collins, D. R. Spring, Chembiochem 2016, 17, 689-692.
161.Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell, A. Chattopadhyay, C. J. O'Connor, F. Zhang, C. Galvagnion, T. Rahman, D. R. Spring, L. S. Itzhaki, Sci. Rep. 2016, 6, 23732.
160.A new Pseudomonas quinolone signal (PQS) binding partner: MexG, J. T. Hodgkinson, J. Gross, Y. R. Baker, D. R. Spring, M. Welch, Chem. Sci. 2016, 7, 2553-2562.
159.An expedient strategy for the diversity-oriented synthesis of macrocyclic compounds with natural product-like characteristics, J. J. Ciardiello, W. R. J. D. Galloway, C. J. O'Connor, H. F. Sore, J. E. Stokes, Y. Wu, D. R. Spring, Tetrahedron 2016, 72, 3567-3578.
158.The Synthesis of Quinolone Natural Products from Pseudonocardia sp., F. Salvaggio, J. T. Hodgkinson, L. Carro-Santos, S. M. Geddis, W. R. J. D. Galloway, M. Welch, D. R. Spring, Eur. J. Org. Chem. 2016, 434-437.
157.New Advances in Diversity Oriented Synthesis, W. R. J. D. Galloway, J. E. Stokes, D. R. Spring, In "Small Molecule Medicinal Chemistry: Strategies and Technologies", ed. W. Czechtizky, P. Hamley 2016, Wiley, 79-101.
156.Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen, T. A. Alanine, W. R. J. D. Galloway, S. Bartlett, J. J. Ciardiello, T. M. McGuire, D. R. Spring, Org. Biomol. Chem. 2016, 14, 1031-1038.

2015

155.Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides, Y. H. Lau, Y. Wu, M. Rossmann, B. X. Tan, P. de Andrade, Y. S. Tan, C. Verma, G. J. McKenzie, A. R. Venkitaraman, M. Hyvonen, D. R. Spring, Angew. Chem. Int. Ed. 2015, 54, 15410-15413.
154.Which microbial factors really are important in Pseudomonas aeruginosa infections?, A. Crousilles, E. Maunders, S. Bartlett, C. Fan, E.-F. Ukor, Y. Abdelhamid, Y. Baker, A. Floto, D. R. Spring, M. Welch, Future Microbiol. 2015, 10, 1825-1836.
153.Overcoming Chemical, Biological and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions, L. Laraia, G. McKenzie, D. R. Spring, A. R. Venkitaraman, D. J. Huggins, Chem. Biol. 2015, 22, 689-703.
152.The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein-Protein Interactions, Y. S. Tan, D. R. Spring, C. Abell, C. S. Verma, J. Chem. Theory Comput. 2015, 11, 3199-3210.
151.Enantioselective Synthesis of Chromanones via a Peptidic Phosphane Catalyzed Rauhut-Currier Reaction, R. J. H. Scanes, O. Grossmann, A. Grossmann, D. R. Spring, Org. Lett. 2015, 17, 2462-2465.
150.A two-component 'double-click' approach to peptide stapling, Y. H. Lau, Y. Wu, P. de Andrade, W. R. J. D. Galloway, D. R. Spring, Nature Protoc. 2015, 10, 585-594.
149.A Diversity-Oriented Synthesis Strategy Enabling the Combinatorial-Type Variation of Macrocyclic Peptidomimetic Scaffolds, A. Isidro-Llobet, K. Hadje Georgiou, W. R. J. D. Galloway, E. Giacomini, M. Hansen, G. Mendez-Abt, Y. S. Tan, L. Carro-Santos, H. F. Sore, D. R. Spring, Org. Biomol. Chem 2015, 13, 4570-4580.
148.Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis, M. S. Frei, M. K. Bilyard, T. A. Alanine, W. R. J. D. Galloway, J. E. Stokes, D. R. Spring, Bioorg. Med. Chem. 2015, 23, 2666-2679.
147.Divergent and concise total syntheses of dihydrochalcones and 5-deoxyflavones recently isolated from Tacca species and Mimosa diplotricha, T. H. Sum, T. J. Sum, J. E. Stokes, W. R. J. D. Galloway, D. R. Spring, Tetrahedron 2015, 71, 4557-4564.
146.Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck-Suzuki reaction, E. Alza, L. Laraia, B. M. Ibbeson, S. Collins, W. R. J. D. Galloway, J. E. Stokes, A. R. Venkitaraman, D. R. Spring, Chem. Sci. 2015, 6, 390-396.
145.Peptide stapling techniques based on different macrocyclisation chemistries, Y. H. Lau, P. de Andrade, Y. Wu, D. R. Spring, Chem. Soc. Rev. 2015, 44, 91-102.

2014

144.Linear Aliphatic Dialkynes as Alternative Linkers for Double-Click Stapling of p53-Derived Peptides, Y. H. Lau, P. de Andrade, G. J. McKenzie, A. R. Venkitaraman, D. R. Spring, Chembiochem 2014, 15, 2680-2683.
143.Multifunctional supramolecular polymer networks as next-generation consolidants for archaeological wood conservation, Z. Walsh, E. R. Janecek, J. T. Hodgkinson, J. Sedlmair, A. Koutsioubas, D. R. Spring, M. Welch, C. J. Hirschmugl, C. Toprakcioglu, J. R. Nitschke, M. Jones, O. A. Scherman, Proc. Natl. Acad. Sci. USA 2014, 111, 17743-17748.
142.Diversity-Oriented Synthesis of Drug-Like Macrocyclic Scaffolds Using an Orthogonal Organo- and Metal Catalysis Strategy, A. Grossmann, S. Bartlett, M. Janecek, J. T. Hodgkinson, D. R. Spring, Angew. Chem. Int. Ed. 2014, 53, 13093-13097.
141.Concise Synthesis of Substituted Quinolizin-4-ones by Ring-Closing Metathesis, T. A. Alanine, W. R. J. D. Galloway, T. M. McGuire, D. R. Spring, Eur. J. Org. Chem. 2014, 2014, 5767-5776.
140.Diversity Oriented Synthesis: Developing New Chemical Tools To Probe and Modulate Biological Systems, W. R. J. D. Galloway, D. Wilcke, F. Nie, K. Hadje-Georgiou, L. Laraia, D. R. Spring, In "Concepts and Case Studies in Chemical Biology", ed. H. Waldmann, P. Janning 2014, Wiley-VCH, 379-389.
139.Arene C-H Functionalisation Using a Removable or Traceless Directing Group Strategy, F. Zhang, D. R. Spring, Chem. Soc. Rev. 2014, 43, 6906-6919.
138.The use of chlorobenzene as a probe molecule in molecular dynamics simulations, Y. S. Tan, D. R. Spring, C. Abell, C. Verma, J. Chem. Inf. Model. 2014, 54, 1821-1827.
137.Toxicity of six plant extracts and two pyridone alkaloids from Ricinus communis against the malaria vector Anopheles gambiae, S. W. Wachira, S. Omar, J. W. Jacob, M. Wahome, H. T. Alborn, D. R. Spring, D. K. Masiga, B. Torto, Parasit. Vectors 2014, 7, 312.
136.Quantitatively Mapping Cellular Viscosity with Detailed Organelle Information via a Designed PET Fluorescent Probe, T. Liu, X. Liu, D. R. Spring, X. Qian, J. Cui, Z. Xu, Sci. Rep. 2014, 4, 5418.
135.Identification of Key Residues That Confer Rhodobacter sphaeroides LPS Activity at Horse TLR4/MD-2, K. L. Irvine, M. Gangloff, C. M. Walsh, D. R. Spring, N. J. Gay, C. E. Bryant, PLoS ONE 2014, 9, e98776.
134.Investigating peptide sequence variations for 'double-click' stapled p53 peptides, Y. H. Lau, P. de Andrade, N. Skold, G. J. McKenzie, A. R. Venkitaraman, C. Verma, D. P. Lane, D. R. Spring, Org. Biomol. Chem. 2014, 12, 4074-4077.
133.Functionalised staple linkages for modulating the cellular activity of stapled peptides, Y. H. Lau, P. de Andrade, S.-T. Quah, M. Rossmann, L. Laraia, N. Skold, T. J. Sum, P. J. E. Rowling, T. L. Joseph, C. Verma, M. Hyvonen, L. S. Itzhaki, A. R. Venkitaraman, C. J. Brown, D. P. Lane, D. R. Spring, Chem. Sci. 2014, 5, 1804-1809.
132.High Content Screening of Diverse Compound Libraries Identifies Potent Modulators of Tubulin Dynamics, L. Laraia, J. Stokes, A. Emery, G. J. McKenzie, A. R. Venkitaraman, D. R. Spring, ACS Med. Chem. Lett. 2014, 5, 598-603.
131.Diversity-oriented synthesis as a tool for identifying new modulators of mitosis, B. M. Ibbeson, L. Laraia, E. Alza, C. J. O' Connor, Y. S. Tan, H. M. L. Davies, G. McKenzie, A. R. Venkitaraman, D. R. Spring, Nature Commun. 2014, 5, 3155.
130.How Diverse Are Diversity Assessment Methods? A Comparative Analysis and Benchmarking of Molecular Descriptor Space, A. Koutsoukas, S. Paricharak, W. R. J. D. Galloway, D. R. Spring, A. P. IJzerman, R. C. Glen, D. Marcus, A. Bender, J. Chem. Inf. Model. 2014, 54, 230-242.

2013

129.Progress towards the development of a new strategy for the highly stereoselective synthesis of alkene-containing macrocyclic ring systems by organocuprate oxidation, W. R. J. D. Galloway, D. R. Spring, Revista de la Societat Catalana de Quimica 2013, 12, 43-49.
128.Surface swarming motility by Pectobacterium atrosepticum is a latent phenotype that requires O antigen and is regulated by quorum sensing, S. D. Bowden, N. Hale, J. C. S. Chung, J. T. Hodgkinson, D. R. Spring, M. Welch, Microbiol. 2013, 159, 2375-2385.
127.Chemical library screening approaches to aid the design of protein-protein inhibitors, L. Laraia, D. R. Spring, In "Understanding and Exploiting Protein-Protein Interactions as Drug Targets", ed. G. Zinzalla 2013, Future Science Ltd, 32-45.
126.Concise Copper-Catalyzed Synthesis of Tricyclic Biaryl Ether-Linked Aza-Heterocyclic Ring Systems, P. Mestichelli, M. J. Scott, W. R. J. D. Galloway, J. Selwyn, J. S. Parker, D. R. Spring, Org. Lett. 2013, 15, 5448-5451.
125.A New Strategy for the Diversity-Oriented Synthesis of Macrocyclic Scaffolds using Multi-Dimensional Coupling, H. S. G. Beckmann, F. Nie, C. E. Hagerman, H. Johansson, Y. S. Tan, D. Wilcke, D. R. Spring, Nature Chem. 2013, 5, 861-867.
124.Design and Synthesis of a Biotinylated Chemical Probe for Detecting the Molecular Targets of an Inhibitor of the Production of the Pseudomonas aeruginosa Virulence Factor Pyocyanin, Y. R. Baker, W. R. J. D. Galloway, J. T. Hodgkinson, D. R. Spring, Molecules 2013, 18, 11783-11796.
123.Virulence in Pectobacterium atrosepticum is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)ppGpp, S. D. Bowden, A. Eyres, J. C. S. Chung, R. E. Monson, A. Thompson, G. P. C. Salmond, D. R. Spring, M. Welch, Mol. Microbiol. 2013, 90, 457-471.
122.Ligand Binding Kinetics of the Quorum Sensing Regulator PqsR, M. Welch, J. T. Hodgkinson, J. Gross, D. R. Spring, T. Sams, Biochem. 2013, 52, 4433-4438.
121.The Basics of Diversity-Oriented Synthesis, K. M. G. O'Connell, W. R. J. D. Galloway, D. R. Spring, In "Diversity-Oriented Synthesis: Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology", ed. A. Trabocchi 2013, Wiley-VCH, 1-26.
120.Combating multi-drug resistant bacteria: current strategies for the discovery of novel antibacterials, K. M. G. O'Connell, J. T. Hodgkinson, H. F. Sore, M. Welch, G. P. C. Salmond, D. R. Spring, Angew. Chem. Int. Ed. 2013, 52, 10706-10733.
119.A Lysosome-Targetable Fluorescent Probe for Imaging Hydrogen Sulfide in Living Cells, T. Liu, Z. Xu, D. R. Spring, J. Cui, Org. Lett. 2013, 15, 2310-2313.
118.Dynamic Combinatorial Chemistry with Novel Dithiol Building-Blocks: Towards New Structurally Diverse and Adaptive Screening Collections, T. M. Postma, W. R. J. D. Galloway, F. B. L. Cougnon, G. D. Pantos, J. E. Stokes, D. R. Spring, Synlett 2013, 24, 765-769.
117.Towards drugging the undruggable: enhancing the scaffold diversity of synthetic small molecule screening collections using diversity-oriented synthesis, W. R. J. D. Galloway, D. R. Spring, Div. Orient. Synth. 2013, 1, 21-28.
116.Mild and Efficient Synthesis of Benzo-Fused 7- and 8-Membered Ring Lactams: a Convenient Approach Towards Biologically Interesting Chemotypes, J. L. Kenwright, W. R. J. D. Galloway, L. Wortmann, D. R. Spring, Syn. Commun. 2013, 43, 1508-1516.

2012

115.Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics, B. Morkunas, W. R. J. D Galloway, M. Wright, B. M. Ibbeson, J. T. Hodgkinson, K. M. O'Connell, N. Bartolucci, M. Della Valle, M. Welch, D. R. Spring, Org. Biomol. Chem. 2012, 10, 8452-8464.
114.A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds, K. M. G. O'Connell, H. S. G. Beckmann, L. Laraia, H. T. Horsley, A. Bender, A. R. Venkitaraman, D. R. Spring, Org. Biomol. Chem. 2012, 10, 7545-7551.
113.Design of a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1 using Ligand-Mapping Simulations, Y. S. Tan, P. Sledz, S. Lang, C. J. Stubbs, D. R. Spring, C. Abell, R. B. Best, Angew. Chem. Int. Ed. 2012, 51, 10078-10081.
112.Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria, W. R. J. D. Galloway, J. T. Hodgkinson, S. Bowden, M. Welch, D. R. Spring, Trends Microbiol. 2012, 20, 449-458.
111.Two-directional synthesis as a tool for diversity-oriented synthesis: Synthesis of alkaloid scaffolds, K. M. G. O'Connell, M. Diaz-Gavilan, W. R. J. D. Galloway, D. R. Spring, Beilstein J. Org. Chem. 2012, 8, 850-860.
110.Preparation of the quorum sensing molecule 2-heptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS) and structurally related analogues with biological activity using a microwave-assisted procedure, J. T. Hodgkinson, W. R. J. D. Galloway, M. Welch, D. R. Spring, Nature Protoc. 2012, 7, 1184-1192.
109.Palladium catalysed cross-coupling of vinyldisiloxanes with benzylic and allylic halides and sulfonates, E. C. Frye, C. J. O' Connor, D. G. Twigg, B. Elbert, L. Laraia, D. G. Hulcoop, A. R. Venkitaraman, D. R. Spring, Chem. Eur. J. 2012, 18, 8774-8779.
108.Diversity-Oriented Synthesis, W. R. J. D. Galloway, R. J. Spandl, A. Bender, G. L. Thomas, M. Diaz-Gavilan, K. M. G. O'Connell, D. R. Spring, In "Chemical Genomics", ed. H. Fu 2012, Cambridge University Press, 39-59.
107.The effect of humidity on the ozonolysis of unsaturated compounds in aerosol particles, J. W. L. Lee, V. Carrascon, P. J. Gallimore, S. J. Fuller, A. Bjorkegren, D. R. Spring, F. D. Pope, M. Kalberer, Phys. Chem. Chem. Phys. 2012, 14, 8023-8031.
106.Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa, J. T. Hodgkinson, W. R. J. D. Galloway, M. Wright, I. K. Mati, R. L. Nicholson, M. Welch, D. R. Spring, Org. Biomol. Chem. 2012, 10, 6032-6044.
105.Diversity-oriented synthesis: producing chemical tools to dissect biology, H. Beckmann, C. J. O' Connor, D. R. Spring, Chem. Soc. Rev. 2012, 41, 4444-4456.
104.Coumarin-Derived Transformable Fluorescent Sensor for Zn2+, Z. Xu, X. Liu, J. Pan, D. R. Spring, Chem. Commun. 2012, 48, 4764-4766.
103.Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity, S. Zheng, L. Laraia, C. J. O' Connor, D. Sorrell, Y. S. Tan, Z. Xu, A. R. Venkitaraman, W. Wu, D. R. Spring, Org. Biomol. Chem. 2012, 10, 2590-2593.
102.A Concise Total Synthesis of Deoxyschizandrin and Exploration of its Anti-Proliferative Effects and those of Structurally Related Derivatives, S. Zheng, S. J. Aves, L. Laraia, W. R. J. D. Galloway, K. G. Pike, W. Wu, D. R. Spring, Chem. Eur. J. 2012, 18, 3193-3198.
101.Diversity-Oriented Synthesis, K. M. G. O'Connell, W. R. J. D. Galloway, B. M. Ibbeson, A. Isidro-Llobet, C. J. O' Connor, D. R. Spring, In "Solid-Phase Organic Synthesis: Concepts, Strategies, and Applications", ed. P. H. Toy, Y. Lam 2012, Wiley, 131-150.
100.Palladium-catalysed cross-coupling of organosilicon reagents, H. F. Sore, W. R. J. D. Galloway, D. R. Spring, Chem. Soc. Rev. 2012, 41, 1845-1866.
99.Synthesis of Highly Substituted Symmetrical 1,3-Dienes via Organocuprate Oxidation, S. J. Aves, K. M. G. O'Connell, K. G. Pike, D. R. Spring, Synlett 2012, 23, 298-300.
98.Novel phosphate derivatives as scaffolds for the preparation of synthetic phosphoserine-based peptides using the Fmoc/t-Bu solid-phase strategy, A. Cilibrizzi, A. Isidro-Llobet, N. Mateu, W. R. J. D. Galloway, D. R. Spring, Synlett 2012, 23, 290-294.

2011

97.Importance of relative humidity in the oxidative ageing of organic aerosols: case study of the ozonolysis of maleic acid aerosol, P. J. Gallimore, P. Achakulwisut, F. D. Pope, J. Davies, D. R. Spring, M. Kalberer, Atmos. Chem. Phys. 2011, 11, 23169-23202.
96.PNA to DNA to Microarray Decoding Facilitates Ligand Discovery, W. R. J. D. Galloway, D. R. Spring, Chem. Biol. 2011, 18, 1209-1210.
95.Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site, V. M. Bolanos-Garcia, T. Lischetti, D. Matak-Vinkovic, E. Cota, P. J. Simpson, D. Y. Chirgadze, D. R. Spring, C. V. Robinson, J. Nilsson, T. L. Blundell, Structure 2011, 19, 1691-1700.
94.Aryl-Aryl Bond Formation by the Fluoride-Free Cross-Coupling of Aryldisiloxanes with Aryl Bromides, C. M. Boehner, E. C. Frye, K. M. G. O'Connell, W. R. J. D. Galloway, H. F. Sore, P. Garcia-Dominguez, D. Norton, D. G. Hulcoop, M. Owen, G. Turner, C. Crawford, H. Horsley, D. R. Spring, Chem. Eur. J. 2011, 17, 13230-13239.
93.2-Heptyl-4-Quinolone, a Precursor of the Pseudomonas Quinolone Signal Molecule, Modulates Swarming Motility in Pseudomonas aeruginosa, D. G. Ha, J. H. Merritt, T. H. Hampton, J. T. Hodgkinson, M. Janecek, D. R. Spring, M. Welch, G. A. O'Toole, J. Bact. 2011, 193, 6770-6780.
92.Stereoselective Synthesis of Disubstituted Butadienes via Copper-Mediated Coupling of Alkenyl Silanes, D. T. Blackwell, W. R. J. D. Galloway, D. R. Spring, Synlett 2011, 2140-2144.
91.A quorum-sensing molecule acts as a morphogen controlling gas vesicle organelle biogenesis and adaptive flotation in an enterobacterium, J. P. Ramsay, N. R. Williamson, D. R. Spring, G. P. C. Salmond, Proc. Natl. Acad. Sci. USA 2011, 108, 14932-14937.
90.5-HT Receptor Modulators, P. B. Kapadnis, J. Bell, R. Hiley, R. C. Glen, D. R. Spring, Patent 2011, 18th August, WO 2011/098776 A1.
89.Efficient Synthesis of Fmoc-Protected Azido Amino Acids, Y-H Lau, D. R. Spring, Synlett 2011, 1917-1919.
88.Chemical Genetics, C. J. O' Connor, L. Laraia, D. R. Spring, Chem. Soc. Rev. 2011, 40, 4332-4345.
87.Small molecules in biology (Editorial), A. Tavassoli, A. D. Hamilton, D. R. Spring, Chem. Soc. Rev. 2011, 40, 4269-4270.
86.Fluorescent Sensing and Discrimination of ATP and ADP Based on Unique Sandwich Assembly of Pyrene-Adenine-Pyrene, Z. Xu, D. R. Spring, J. Yoon, Chem. Asian J. 2011, 6, 2114-2122.
85.1-(3,5-Dinitrobenzoyl)-4-methylpiperazine, W. R. J. D. Galloway, D. R. Spring, In: e-EROS Encyclopedia of Reagents for Organic Synthesis, ed. L. A. Paquette, D. Crich, P. L. Fuchs, G. Molander 2011, rn01350.
84.Regioselectivity in Thermal Rhodium(II)-Catalysed Buchner-Type Reactions of Substituted Aryl Halides: Studies towards the Synthesis of Halide-Substituted Cycloheptatrienes, E. E. Wyatt, W. R. J. D. Galloway, D. R. Spring, Synlett 2011, 1449-1453.
83.Chemogenomics Approaches for Receptor Deorphanization and Extensions of the Chemogenomics Concept to Phenotypic Space, E. van der Horst, J. E. Peironcely, G. J. P. van Westen, O. O. van den Hoven, W. R. J. D. Galloway, D. R. Spring, J. K. Wegner, H. W. T. van Vlijmen, A. P. IJzerman, J. P. Overington, A. Bender, Curr. Top. Med. Chem. 2011, 11, 1964-1977.
82.Robust routes for the synthesis of N-acylated-L-homoserine lactone (AHL) quorum sensing molecules with high levels of enantiomeric purity, J. T. Hodgkinson, W. R. J. D. Galloway, M. Casoli, H. Keane, X. Su, G. P. C. Salmond, M. Welch, D. R. Spring, Tetrahedron Lett. 2011, 52, 3291-3294.
81.The Serratia LuxR family regulator CarR39006 activates transcription independently of cognate quorum sensing signals, S. Poulter, T. M. Carlton, D. R. Spring, G. P. C. Salmond, Mol. Microbiol. 2011, 80, 1120-1131.
80.Diversity-Oriented Synthesis of Macrocyclic Peptidomimetics, A. Isidro-Llobet, T. Murillo, P. Bello, A. Cilibrizzi, J. T. Hodgkinson, W. R. J. D. Galloway, A. Bender, M. Welch, D. R. Spring, Proc. Natl. Acad. Sci. USA 2011, 108, 6793-6798.
79.Controlling the contents of microdroplets by exploiting the permeability of PDMS, J. Shim, S. N. Patil, J. T. Hodgkinson, S. D. Bowden, D. R. Spring, M. Welch, W. T. S. Huck, F. Hollfelder, C. Abell, Lab Chip 2011, 11, 1132-1137.
78.Rational Methods for the Selection of Diverse Screening Compounds, D. J. Huggins, A. R. Venkitaraman, D. R. Spring, ACS Chem. Bio. 2011, 6, 208-217.
77.Novel and Efficient Copper-Catalysed Synthesis of Nitrogen-Linked Medium-Ring Biaryls, J. L. Kenwright, W. R. J. D. Galloway, D. T. Blackwell, A. Isidro-Llobet, J. Hodgkinson, L. Wortmann, S. D. Bowden, M. Welch, D. R. Spring, Chem. Eur. J. 2011, 17, 2981-2986.
76.Better leads come from diversity, W. R. J. D. Galloway, D. R. Spring, Nature 2011, 470, 43.
75.Induction-Driven Stabilization of the Anion-pi Interaction in Electron-Rich Aromatics as the Key to Fluoride Inclusion in Imidazolium-Cage Receptors, Z. Xu, N. J. Singh, S. K. Kim, D. R. Spring, K. S. Kim, J. Yoon, Chem. Eur. J. 2011, 17, 1163-1170.
74.Quorum Sensing in Gram-Negative Bacteria: Small-Molecule Modulation of AHL and AI-2 Quorum Sensing Pathways, W. R. J. D. Galloway, J. T. Hodgkinson, S. D. Bowden, M. Welch, D. R Spring, Chem. Rev. 2011, 111, 28-67.
73.Vinyldisiloxanes: their synthesis, cross coupling and applications, H. F. Sore, C. M. Boehner, L. Laraia, P. Logoteta, C. Prestinari, M. Scott, K. Williams, W. R. J. D. Galloway, D. R. Spring, Org. Biomol. Chem. 2011, 9, 504-515.
72.Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues, J. T. Hodgkinson, W. R. J. D. Galloway, S. Saraf, I. R. Baxendale, S. V. Ley, M. Ladlow, M. Welch, D. R. Spring, Org. Biomol. Chem. 2011, 9, 57-61.

2010

71.Synthesis of Highly Substituted Symmetrical 1,3-Dienes via Tandem Carbocupration and Organocuprate Oxidation, S. J. Aves, K. G. Pike, D. R. Spring, Synlett 2010, 2839-2842.
70.Discovery of a quorum sensing modulator pharmacophore by 3D small-molecule microarray screening, D. M. Marsden, R. L. Nicholson, M. E. Skindersoe, W. R. J. D. Galloway, H. F. Sore, M. Givskov, G. P. C. Salmond, M. Ladlow, M. Welch, D. R. Spring, Org. Biomol. Chem. 2010, 8, 5313-5323.
69.Diversity-oriented synthesis as a tool for the discovery of novel biologically functional small molecules, W. R. J. D. Galloway, A. Isidro-Llobet, D. R. Spring, Nature Commun. 2010, 1, 80.
68.High throughput 'catch-and-release' synthesis within spatially discrete gel arrays, C. M. Boehner, D. M. Marsden, H. F. Sore, D. Norton, D. R. Spring, Tetrahedron Lett. 2010, 51, 5930-5932.
67.Discovery of a Highly Selective Turn-on Fluorescent Probe for Ag+, Z. Xu, S. Zheng, J. Yoon, D. R. Spring, Analyst 2010, 135, 2554-2559.
66.Structure-Activity Analysis of the Pseudomonas Quinolone Signal Molecule, J. Hodgkinson, S. D. Bowden, W. R. J. D. Galloway, D. R. Spring, M. Welch, J. Bacteriol. 2010, 192, 3833-3837.
65.Diversity-Oriented Synthesis of Disubstituted Alkenes using Masked Silanols, H. F. Sore, D. T. Blackwell, S. J. F. MacDonald, D. R. Spring, Org. Lett. 2010, 12, 2806-2809.
64.Fluorescent Chemosensors for Zn2+, Z. Xu, J. Yoon, D. R. Spring, Chem. Soc. Rev. 2010, 39, 1996-2006.
63.A selective and ratiometric Cu2+ fluorescent probe based on naphthalimide excimer-monomer switching, Z. Xu, J. Yoon, D. R. Spring, Chem. Commun. 2010, 46, 2563-2565.
62.Engineering of new prodigiosin-based biosensors of Serratia for facile detection of short-chain N-acyl homoserine lactone quorum sensing molecules, S. Poulter, T. M. Carlton, X. Su, D. R. Spring, G. P. C. Salmond, Environ. Microbio. Reports 2010, 2, 322-328.
61.Development of off-on fluorescent probes for heavy and transition metal ions, Z. Xu, S. J. Han, C. Lee, J. Yoon, D. R. Spring, Chem. Commun. 2010, 46, 1679-1681.
60.Ratiometric fluorescent and colorimetric sensors for Cu2+ based on 4,5-disubstituted-1,8-naphthalimide and sensing cyanide via a Cu2+ displacement approach, Z. Xu, J. Pan, D. R. Spring, J. Cui, J. Yoon, Tetrahedron 2010, 66, 1678-1683.
59.Zn2+ Triggered Amide Tautomerization Produces a Highly Zn2+ Selective, Cell-Permeable and Ratiometric Fluorescent Sensor, Z. Xu, K. Baek, H. N. Kim, J. Cui, X. Qian, D. R. Spring, I. Shin, J. Yoon, J. Am. Chem. Soc. 2010, 132, 601-610.
58.Diversity-oriented synthesis of bicyclic and tricyclic alkaloids, M. Diaz Gavilan, W. R. J. D. Galloway, K. M. G. O'Connell, J. T. Hodgkinson, D. R. Spring, Chem. Commun. 2010, 46, 776-778.
57.The molecular basis of the host response to lipopolysaccharide, C. E. Bryant, D. R. Spring, M. Gangloff, N. J. Gay, Nature Rev. Microbio. 2010, 8, 8-14.

2009

56.3D small-molecule microarrays, D. M. Marsden, R. L. Nicholson, M. Ladlow, D. R. Spring, Chem. Commun. 2009, 7107-7109.
55.Oxidation of Organocopper Compounds, S. J. Aves, D. R. Spring, In "The Chemistry of Organocopper Compounds", ed. Z. Rappoport and I. Marek 2009, Wiley, 585-602.
54.An Introduction to Diversity-Oriented Synthesis, R. J. Spandl, G. L. Thomas, M. Diaz Gavilan, K. M. G. O'Connell, D. R. Spring, In "Linker Strategies in Solid-Phase Organic Synthesis", ed. P. Scott 2009, Wiley, 241-262.
53.The synthesis of biaryl-containing medium ring systems by organocuprate oxidation: applications in the total synthesis of ellagitannin natural products, X. Su, G. L. Thomas, W. R. J. D. Galloway, D. S. Surry, R. J. Spandl, D. R. Spring, Synthesis 2009, 3880-3896.
52.Mastering the Chemical Language of Bacteria, W. R. J. D. Galloway, J. T. Hodgkinson, M. Welch, D. R. Spring, Chem. Biol. 2009, 16, 913-914.
51.Is synthesis the main hurdle for the generation of diversity in compound libraries for screening?, W. R. J. D. Galloway, D. R. Spring, Expert Opin. Drug Discov. 2009, 4, 467-472.
50.The discovery of antibacterial agents using diversity oriented synthesis, W. R. J. D. Galloway, A. Bender, M. Welch, D. R. Spring, Chem. Commun. 2009, 2446-2462.
49.Fluoride-free cross coupling using vinyldisiloxanes, H. F. Sore, C. M. Boehner, S. J. F. MacDonald, D. Norton, D. J. Fox, D. R. Spring, Org. Biomol. Chem. 2009, 7, 1068-1071.
48.Synthesis of Unprecedented Scaffold Diversity, W. R. J. D. Galloway, M. Diaz Gavilan, A. Isidro Llobet, D. R. Spring, Angew. Chem. Int. Ed. 2009, 48, 1194-1196.
47.Towards quorum-quenching catalytic antibodies, P. B. Kapadnis, E. Hall, M. Ramstedt, W. R. J. D. Galloway, M. Welch, D. R. Spring, Chem. Commun. 2009, 538-540.

2008

46.Using chemical probes to investigate the sub-inhibitory effects of azithromycin, F. G. Glansdorp, R. J. Spandl, J. E. Swatton, O. Loiseleur, M. Welch, D. R. Spring, Org. Biomol. Chem. 2008, 6, 4120-4124.
45.Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis, E. E. Wyatt, W. R. J. D. Galloway, G. L. Thomas, M. Welch, O. Loiseleur, A. T. Plowright, D. R. Spring, Chem. Commun. 2008, 4962-4964.
44.Synthesis of a Biotin Labeled Quorum Sensing Molecule; Towards a General Method for Target Identification, R. J. Spandl, R. L. Nicholson, D. M. Marsden, J. T. Hodgkinson, X. Su, G. L. Thomas, G. P. C. Salmond, M. Welch, D. R. Spring, Synlett 2008, 2122-2126.
43.Gemmacin B: bringing diversity back into focus, A. Robinson, G. L. Thomas, R. J. Spandl, M. Welch, D. R. Spring, Org. Biomol. Chem. 2008, 6, 2978-2981.
42.Exploiting Domino Enyne Metathesis Mechanisms For Skeletal Diversity Generation, R. J. Spandl, H. Rudyk, D. R. Spring, Chem. Commun. 2008, 3001-3003.
41.The chemistry-biology interface, D. R. Spring, Chem. Soc. Rev. 2008, 37, 1293.
40.Diversity-oriented synthesis, R. J. Spandl, M. Diaz Gavilan, K. M. G. O'Connell, G. L. Thomas, D. R. Spring, Chem. Rec. 2008, 8, 129-142.
39.Total Synthesis of Sanguiin H-5, X. Su, D. S. Surry, R. J. Spandl, D. R. Spring, Org. Lett. 2008, 10, 2593-2596.
38.2-Methoxycyclopentyl analogues of a Pseudomonas aeruginosa quorum sensing modulator, L. Y. W. Lee, T. Hupfield, R. L. Nicholson, J. T. Hodgkinson, X. Su, G. L. Thomas, G. P. C. Salmond, M. Welch, D. R. Spring, Mol. Biosyst. 2008, 4, 505-507.
37.Anti-MRSA Agent Discovery Using Diversity-Oriented Synthesis, G. L. Thomas, R. J. Spandl, F. G. Glansdorp, M. Welch, A. Bender, J. Cockfield, J. A. Lindsay, C. Bryant, D. F. J. Brown, O. Loiseleur, H. Rudyk, M. Ladlow, D. R. Spring, Angew. Chem. Int. Ed. 2008, 47, 2808-2812.
36.Diversity-oriented synthesis; a spectrum of approaches and results, R. J. Spandl, A. Bender, D. R. Spring, Org. Biomol. Chem. 2008, 6, 1149-1158.

2007

35.Learning the Language of Bacteria, J. T. Hodgkinson, M. Welch, D. R. Spring, ACS Chem. Biol. 2007, 2, 715-717.
34.Fluorous tagged small molecule microarrays, R. L. Nicholson, M. L. Ladlow, D. R. Spring, Chem. Commun. 2007, 3906-3908.
33.Design and chance in the self-assembly of macromolecules, J. A. R. Worrall, M. Gorna, X. Y. Pei, D. R. Spring, R. L. Nicholson, B. F. Luisi, Biochem. Soc. Trans. 2007, 35(3), 502-507.
32.Small-Molecule Screening: Advances in Microarraying and Cell-Imaging Technologies, R. L. Nicholson, M. Welch, M. Ladlow, D. R. Spring, ACS Chem. Biol. 2007, 2, 24-30.

2006

31.Variations on a theme: diverse N-acyl homoserine lactone-mediated quorum sensing mechanisms in Gram-negative bacteria, D. Smith, J.-H. Wang, J. E. Swatton, P. Davenport, B. Price, H. Mikkelsen, H. Stickland, K. Nishikawa, N. Gardiol, D. R. Spring, M. Welch, Sci. Prog. 2006, 89, 167-211.
30.Enriching chemical space with diversity-oriented synthesis, G. L. Thomas, E. E. Wyatt, D. R. Spring, Curr. Opin. Drug Discov. Dev. 2006, 9, 700-712.
29.Copper Catalyzed Oxidation of Organozinc Halides, X. Su, D. J. Fox, D. T. Blackwell, K. Tanaka, D. R. Spring, Chem. Commun. 2006, 3883-3885.
28.Skeletal diversity construction via a branching synthetic strategy, E. E. Wyatt, S. Fergus, W. R. J. D. Galloway, A. Bender, D. J. Fox, A. T. Plowright, A. S. Jessiman, M. Welch, D. R. Spring, Chem. Commun. 2006, 3296-3298.
27.Metabolic and regulatory engineering of Serratia marcescens: mimicking phage-mediated horizontal acquisition of antibiotic biosynthesis and quorum sensing capacities, S. J. Coulthurst, N. R. Williamson, A. K. P. Harris, D. R. Spring, G. P. C. Salmond, Microbiol. 2006, 152, 1899-1911.
26.Diversity Oriented Synthesis: A Challenge for Synthetic Chemists, A. Bender, S. Fergus, W. R. J. D. Galloway, F. G. Glansdorp, D. M. Marsden, R. L. Nicholson, R. J. Spandl, G. L. Thomas, E. E. Wyatt, R. C. Glen, D. R. Spring, In 'Chemical Genomics: Small Molecule Probes to Study Cellular Function' 2006, 58, 47-60.
25.The oxidation of organocuprates - an offbeat strategy for synthesis, D. S. Surry, D. R. Spring, Chem. Soc. Rev. 2006, 35, 218-225.
24.Immunomodulatory effects of Pseudomonas aeruginosa quorum sensing small molecule probes on mammalian macrophages, G. L. Thomas, C. M. Bohner, H. E. Williams, C. M. Walsh, M. Ladlow, M. Welch, C. E. Bryant, D. R. Spring, Mol. Biosyst. 2006, 2, 132-137.

2005

23.Synthesis and utilization of functionalized polystyrene resins, G. L. Thomas, C. Bohner, M. Ladlow, D. R. Spring, Tetrahedron 2005, 61, 12153-12159.
22.Cell-cell communication in Gram-negative bacteria, M. Welch, H. Mikkelsen, J. E. Swatton, D. S. Smith, G. L. Thomas, F. G. Glansdorp, D. R. Spring, Mol. Biosyst. 2005, 1, 196-202.
21.Structure-activity relationships of Erwinia carotovora quorum sensing signaling molecules, M. Welch, J. M. Dutton, F. G. Glansdorp, G. L. Thomas, D. S. Smith, S. J. Coulthurst, A. M. L. Barnard, G. P. C. Salmond, D. R. Spring, Bioorg. Med. Chem. Lett. 2005, 15, 4235-4238.
20.Assessment of structural diversity in combinatorial synthesis, S. Fergus, A. Bender, D. R. Spring, Curr. Opin. Chem. Biol. 2005, 9, 304-309.
19.Chemical genetics to chemical genomics: small molecules offer big insights, D. R. Spring, Chem. Soc. Rev. 2005, 34, 472-482.
18.Aryl-aryl coupling via directed lithiation and oxidation, D. S. Surry, D. J. Fox, S. J. F. Macdonald, D. R. Spring, Chem. Commun. 2005, 2589-2590.
17.Medium-Ring and Iodinated Biaryl Synthesis by Organocuprate Oxidation, D. S. Surry, X. Su, D. J. Fox, V. Franckevicius, S. J. F. Macdonald, D. R. Spring, Angew. Chem. Int. Ed. 2005, 44, 1870.

2004

16.Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips, J. Huang, H. Zhu, S. J. Haggarty, D. R. Spring, H. Hwang, F. Jin, M. Snyder, S. L. Schreiber, Proc. Natl. Acad. Sci. USA 2004, 101, 16594-16599.
15.Synthesis and stability of small molecule probes for Pseudomonas aeruginosa quorum sensing modulation, F. G. Glansdorp, G. L. Thomas, J. K. Lee, J. M. Dutton, G. P. C. Salmond, M. Welch, D. R. Spring, Org. Biomol. Chem. 2004, 2, 3329-3336.
14.Highlights from the 39th ESF/EUCHEM Conference on Stereochemistry, C. J. Hayes, D. R. Spring, Chem. Commun. 2004, 2365-2367.
13.Communications blackout? Do N-acylhomoserine-lactone-degrading enzymes have any role in quorum sensing?, D. M. Roche, J. T. Byers, D. S. Smith, F. G. Glansdorp, D. R. Spring, M. Welch, Microbiology 2004, 150, 2023-2028.
12.Complete functionalisation of small and large diameter bromopolystyrene beads; applications for solid-supported reagents, scavengers and diversity-oriented synthesis, G. L. Thomas, M. Ladlow, D. R. Spring, Org. Biomol. Chem. 2004, 2, 1679-1681.

2003

11.Chemical Genetics to Chemical Genomics, D. R. Spring, ChemBiol Newsletter 2003, 4, 4-5.
10.Diversity-oriented synthesis; a challenge for synthetic chemists, D. R. Spring, Org. Biomol. Chem. 2003, 1, 3867-3870.

2002

9.Diversity-Oriented Synthesis Of Biaryl-Containing Medium Rings Using A One Bead-One Stock Solution Platform, D. R. Spring, S. Krishnan, H. E. Blackwell, S. L. Schreiber, J. Am. Chem. Soc. 2002, 124, 1354-1363.

2001

8.A One Bead, One Stock Solution Approach To Chemical Genetics, Part 2, P. A. Clemons, A. N. Koehler, B. K. Wagner, T. G. Sprigings, D. R. Spring, R. W. King, M. A. Foley, S. L. Schreiber, Chem. Biol. 2001, 8, 1183-1195.

2000

7.Towards Diversity-Oriented, Stereoselective Syntheses of Biaryl- or Bis(aryl)metal-Containing Medium Rings, D. R. Spring, S. Krishnan, S. L. Schreiber, J. Am. Chem. Soc. 2000, 122, 5656-5657.

1999

6.Studies on the Biomimetic Synthesis of the Manzamine Alkaloids, J. E. Baldwin, T. D. W. Claridge, A. J. Culshaw, F. A. Heupel, V. Lee, D. R. Spring, R. C. Whitehead, Chem. Eur. J. 1999, 5, 3153-3161.

1998

5.Investigations into the Manzamine Alkaloid Biosynthetic Hypothesis, J. E. Baldwin, T. D. W. Claridge, A. J. Culshaw, F. A. Heupel, V. Lee, D. R. Spring, R. C. Whitehead, R. J. Boughtflower, I. M. Mutton, R. J. Upton, Angew. Chem. Int. Ed. 1998, 37, 2661-2663.
4.Efficient Synthesis of the Sponge Alkaloids Cyclostellettamines A-F, J. E. Baldwin, D. R. Spring, C. E. Atkinson, V. Lee, Tetrahedron 1998, 54, 13655-13680.
3.A Novel Diels-Alder Approach to Hydroisoquinolines, J. E. Baldwin, D. R. Spring, R. C. Whitehead, Tetrahedron Lett. 1998, 39, 5417-5420.

1997

2.An Approach to the Manzamine Alkaloids Modelled on a Biogenetic Theory, J. E. Baldwin, L. Bischoff, T. D. W. Claridge, F. A. Heupel, D. R. Spring, R. C.Whitehead, Tetrahedron 1997, 53, 2271-2290.
1.A biomimetic approach to the manzamine alkaloids, D. R. Spring, J. E. Baldwin, R. C. Whitehead, L. Bischoff, T. D. W. Claridge, FASEB J. 1997, 11, 211.